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KMID : 1024519980070010062
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Journal of the Environmental Sciences
1998 Volume.7 No. 1 p.62 ~ p.66
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Interaction of Hornet Venom and its Derivatives in the Phospholipid Membrane Environment
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Lee Bong-Hun
Park Heung-Jai
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Abstract
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Toxic Mastoparan B(MP-B) which is purified from the venom of the hornet Vespa basalis is a cationic amphlphilic tetradecapeptide. MP-B and Its Ala-substituted analogues were synthesized by solld phase method and the toxic peptide-membrane interactions were examined by circular dichroism(CD) spectra, fluorescence spectra, and leakage abilities in phospholipid membranes. In the presence of phospholipid vesicles, synthetic MP-B and its analogues formed amphiphilic
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KEYWORD
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hornet venom, toxic peptide, leakage ability, phospholipid membrane
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